Research Library

Kamkaen N, Chittasupho C, Vorarat S, Tadtong S, Phrompittayarat W, Okonogi S, Kwankhao P - Molecules

Mucuna pruriens whole seed extract showed superior neuroprotective and acetylcholinesterase inhibitory effects compared to synthetic L-DOPA alone.

Guo J, Chen H, Zhang X, Lou W, Zhang P, Qiu Y, Zhang C, Wang Y, Liu WJ - Oxidative Medicine and Cellular Longevity

Berberine significantly improved blood glucose and lipid profiles, comparable to metformin, supporting metabolic brain health.

Dourado NS, Souza CDS, de Almeida MMA, Bispo da Silva A, Dos Santos BL, Silva VDA, De Assis AM, da Silva JS, Souza DO, Costa MFD, Butt AM, Costa SL - Frontiers in Aging Neuroscience

Apigenin demonstrates neuroprotective effects, enhances neuroplasticity, and reduces anxiety through multiple mechanisms.

Shinjyo N, Waddell G, Green J - Journal of Evidence-Based Integrative Medicine

Valerian consistently improved sleep quality across 60 studies, with enhanced effects when combined with hops or lemon balm.

Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR - Nature Communications

Nicotinamide riboside safely and effectively increased NAD+ levels in middle-aged and older adults.

Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D - Experimental Gerontology

Creatine supplementation improves short-term memory and reasoning, especially in vegetarians and during mental stress.

Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR - American Journal of Geriatric Psychiatry

Curcumin supplementation improved memory by 28% and reduced brain amyloid and tau accumulation over 18 months.

Zhu ZG, Sun MX, Zhang WL, Wang WW, Jin YM, Xie CL - Journal of the Neurological Sciences

CoQ10 supplementation (1200mg daily) significantly improved motor symptoms in Parkinson's disease patients.

Kean JD, Downey LA, Stough C - Complementary Therapies in Medicine

Bacopa monnieri progressively improved memory consolidation and learning over 12 weeks in older adults.

Haase J, Halama P, Hörr R - Aging Clinical and Experimental Research

Ginkgo biloba (240mg daily) improved dual-task walking, memory, and quality of life in mild cognitive impairment over 6 months.

Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI - Cell Metabolism

Long-term NMN supplementation in mice mitigated age-related physiological decline across multiple organ systems by boosting NAD+ levels.

Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS - Neurology

Resveratrol (up to 2g daily) stabilized brain volume loss and reduced neuroinflammation biomarkers in Alzheimer's patients.

Blessing EM, Steenkamp MM, Manzanares J, Marmar CR - Neurotherapeutics

CBD shows significant anxiolytic effects across multiple anxiety disorders in both animal and human studies.

Tan MS, Yu JT, Tan CC, Wang HF, Meng XF, Wang C, Jiang T, Zhu XC, Tan L - Journal of Alzheimer's Disease

Ginkgo biloba (240mg daily) modestly but significantly improves cognition and daily function in dementia patients.

Colzato LS, de Haan AM, Hommel B - Psychological Research

L-tyrosine (2g) acutely enhanced creative and convergent thinking abilities in healthy adults.

Battleday RM, Brem AK - European Neuropsychopharmacology

Modafinil reliably enhances attention, executive function, and learning in healthy adults, especially on complex tasks.

Glade MJ, Smith K - Nutrition

Phosphatidylserine supplementation improved memory, attention, and verbal recall in elderly individuals with cognitive complaints.

Cropley M, Banks AP, Boyle J - Phytotherapy Research

Rhodiola rosea (400mg daily) significantly reduced stress symptoms and improved mood within one week of treatment.

Pratte MA, Nanavati KB, Young V, Morley CP - Journal of Alternative and Complementary Medicine

Ashwagandha consistently and significantly reduced anxiety in all reviewed human trials across various populations.

Shetty RA, Ikonne US, Forster MJ, Sumien N - Experimental Gerontology

CoQ10 supplementation reduced oxidative stress and supported mitochondrial energy production relevant to cognitive health.