Ginkgo biloba special extract EGb 761 improves dual-task walking in patients with MCI: a randomised, double-blind, placebo-controlled exploratory study

This randomized, double-blind, placebo-controlled trial examined Ginkgo biloba EGb 761 on dual-task walking performance in 160 patients with mild cognitive impairment. Participants received 240mg daily or placebo for 6 months.

The Ginkgo group showed significant improvements in dual-task walking performance - the ability to walk while simultaneously performing a cognitive task. This ability reflects executive function and attention allocation, which are often impaired early in cognitive decline.

Improvements were also observed in memory and quality of life measures. Dual-task performance is particularly important for daily functioning and fall prevention in older adults. The study provides evidence that Ginkgo biloba can improve functional abilities beyond just cognitive test scores. The standardized extract was well-tolerated throughout the 6-month study period. Ginkgo's mechanisms include improved cerebral blood flow, antioxidant effects, and protection against beta-amyloid toxicity.