Phosphatidylserine and the human brain
Key Finding
Phosphatidylserine supplementation improved memory, attention, and verbal recall in elderly individuals with cognitive complaints.
Plain-English Summary
This meta-analysis reviewed clinical trials examining phosphatidylserine (PS) supplementation for cognitive impairment in older adults. Studies used doses of 100-300mg daily over periods of 6-12 weeks.
Results showed that PS supplementation significantly improved memory, attention, and language skills in elderly subjects with cognitive complaints. Benefits were most pronounced for verbal recall and name-face association tasks.
PS is a phospholipid that makes up a significant portion of brain cell membranes. It plays a key role in cell signalling, neurotransmitter release, and synaptic activity. PS levels decline with age, and supplementation may help restore membrane fluidity and function. The compound was well-tolerated across all reviewed studies.