Nootropic profile
Apigenin
A flavonoid found abundantly in chamomile that inhibits CD38 to preserve NAD+ levels, promotes BDNF expression, modulates GABA receptors for anxiolytic effects, and supports healthy sleep architecture.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Apigenin?
Apigenin (4',5,7-trihydroxyflavone) is a naturally occurring flavonoid found in high concentrations in chamomile (Matricaria chamomilla), parsley, celery, and other plants.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Standard supplement dosage: 50-100 mg of apigenin per day
- Sleep and relaxation: 50 mg taken 30-60 minutes before bed
- NAD+ preservation: 50-100 mg daily, taken at any time
- Chamomile tea equivalent: A strong cup of chamomile tea provides approximately 3-10 mg of apigenin - well below supplement doses
- Bioavailability: Apigenin has relatively low oral bioavailability. Taking with a source of fat may improve absorption
Watch out for
- Generally safe: Apigenin has a long history of dietary exposure through chamomile and other food sources
- Sedation at high doses: Higher doses (200+ mg) may cause excessive drowsiness. Do not drive or operate machinery after taking high doses
- Drug interactions: May inhibit certain CYP450 enzymes. Use caution with medications metabolised by CYP1A2, CYP2C9, or CYP3A4
- Pregnancy: Insufficient data for high-dose apigenin supplements during pregnancy. Chamomile tea in moderation is generally considered safe
- Hormone sensitivity: Mild aromatase inhibition and possible oestrogenic activity at high doses - consult a doctor if you have a hormone-sensitive condition
The science, if you're curious.
- Potently inhibits CD38 (a NADase), preserving cellular NAD+ levels and supporting sirtuin activity and mitochondrial function
- Binds to the benzodiazepine binding site on GABA-A receptors as a positive allosteric modulator, producing anxiolytic and mildly sedative effects without...
- Increases brain-derived neurotrophic factor expression, supporting neuroplasticity and neurogenesis
- Inhibits NF-kB activation and reduces microglial production of TNF-alpha, IL-1beta, and nitric oxide
Where to find it
- Isolated apigenin capsules: Available from nootropic and longevity supplement retailers in 50-100 mg capsules
- Chamomile extract: Standardised chamomile extracts with specified apigenin content (1.2-3% apigenin)
- Chamomile tea: Provides lower but meaningful doses of apigenin for daily relaxation
- Food sources: Parsley (the richest dietary source), celery, chamomile, thyme, and peppermint
The research
Frequently asked
A flavonoid found abundantly in chamomile that inhibits CD38 to preserve NAD+ levels, promotes BDNF expression, modulates GABA receptors for anxiolytic effects, and supports healthy sleep architecture.
The main benefits people report from Apigenin are: Anxiety & Calm, Cognitive Enhancement, Longevity, Mood, Sleep, Stress Relief.
Standard supplement dosage: 50-100 mg of apigenin per daySleep and relaxation: 50 mg taken 30-60 minutes before bedNAD+ preservation: 50-100 mg daily, taken at any timeChamomile tea equivalent: A strong cup of chamomile tea provides approximately 3-10 mg of apigenin - well below supplement dosesBioa...
Generally safe: Apigenin has a long history of dietary exposure through chamomile and other food sourcesSedation at high doses: Higher doses (200+ mg) may cause excessive drowsiness. Do not drive or operate machinery after taking high dosesDrug interactions: May inhibit certain CYP450 enzymes. Use c...
Potently inhibits CD38 (a NADase), preserving cellular NAD+ levels and supporting sirtuin activity and mitochondrial functionBinds to the benzodiazepine binding site on GABA-A receptors as a positive allosteric modulator, producing anxiolytic and mildly sedative effects without...Increases brain-der...
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