Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults
Key Finding
Resveratrol (200mg daily) improved memory retention and hippocampal function in healthy older adults over 26 weeks.
Plain-English Summary
This randomized, double-blind, placebo-controlled trial investigated the effects of resveratrol supplementation on memory and brain function in 46 healthy older adults. Participants received 200mg of resveratrol or placebo daily for 26 weeks.
The resveratrol group showed significant improvements in memory retention compared to placebo. Functional MRI scans revealed increased functional connectivity in the hippocampus, a brain region critical for memory formation. Resveratrol also improved glucose metabolism and insulin sensitivity.
The study provides evidence that resveratrol may enhance memory through multiple mechanisms, including improved brain metabolism, enhanced hippocampal function, and better vascular health. Body mass index decreased in the resveratrol group, and participants showed reduced levels of glycated hemoglobin (HbA1c), suggesting improved long-term glucose control. Resveratrol was well-tolerated throughout the study period.