Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial

This double-blind, placebo-controlled trial investigated the effects of Lion's Mane mushroom (Hericium erinaceus) on 30 Japanese adults aged 50-80 with mild cognitive impairment. Participants consumed 250mg tablets containing 96% mushroom extract three times daily for 16 weeks.

Cognitive function was assessed using the Hasegawa Dementia Scale at weeks 8, 12, and 16. The Lion's Mane group showed significantly increased scores at each testing point, indicating progressive improvement in cognitive function. In contrast, the placebo group showed no significant changes.

Notably, cognitive improvements declined after participants stopped taking the supplement at week 16, suggesting continued supplementation may be necessary to maintain benefits. No adverse effects were observed during the study period, and researchers concluded that Lion's Mane is a safe and effective option for preventing cognitive decline.