Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression
Key Finding
PQQ stimulates the creation of new mitochondria and improves cellular energy production.
Plain-English Summary
This preclinical study investigated the mechanisms by which PQQ (pyrroloquinoline quinone) affects mitochondrial function. Researchers examined PQQ's effects on mitochondrial biogenesis in cell cultures and animal models.
Results demonstrated that PQQ stimulates the creation of new mitochondria through activation of CREB phosphorylation and increased expression of PGC-1alpha, a master regulator of mitochondrial biogenesis. PQQ also improved mitochondrial efficiency and function.
Mitochondria are the energy powerhouses of cells, and brain cells are particularly dependent on optimal mitochondrial function. By promoting mitochondrial health and increasing mitochondrial number, PQQ may support cognitive function, energy levels, and neuroprotection. Human studies with 20mg daily PQQ have shown improvements in energy and cognitive function. PQQ is found naturally in foods but in very small amounts, making supplementation potentially beneficial.