Nootropic profile
Tianeptine
An atypical antidepressant with a unique glutamatergic and mu-opioid receptor mechanism that promotes hippocampal neuroplasticity, enhances stress resilience, and improves cognitive function under depressive conditions - prescribed in over 60 countries as Stablon and Coaxil.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Tianeptine?
Tianeptine is a clinically approved atypical antidepressant that defies conventional classification.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Standard clinical dosage: 12.5 mg three times daily (37.5 mg total per day), the dose used in virtually all clinical trials and approved prescribing guidelines
- Sodium form: Tianeptine sodium is the original pharmaceutical form with rapid absorption and shorter duration, requiring three-times-daily dosing
- Sulfate form: Tianeptine sulfate has slower absorption and longer half-life, often dosed at 25 mg twice daily for more sustained effects
- Nootropic use: Many nootropic users employ 12.5 mg once or twice daily rather than the full clinical dose, reporting cognitive and mood benefits at lower...
- Timing: Take before meals for optimal absorption. Tianeptine sodium reaches peak plasma concentration within 1-2 hours
Watch out for
- Addiction potential: The mu-opioid receptor agonism creates genuine abuse liability, particularly with the sodium form at doses exceeding clinical...
- Regulatory status: Prescription medication in Europe, Asia, and Latin America. Unscheduled but increasingly regulated in the US - banned in several states...
- Withdrawal symptoms: Abrupt cessation after prolonged high-dose use can produce opioid-like withdrawal including anxiety, insomnia, muscle aches, and...
- Drug interactions: Do not combine with MAOIs, other opioid agonists, or CNS depressants. Caution with serotonergic drugs due to potential for serotonin...
- Hepatic considerations: Primarily metabolised by the liver via beta-oxidation. Dose reduction recommended in patients with severe hepatic impairment or...
The science, if you're curious.
- Acts as a full agonist at mu-opioid receptors, contributing to its antidepressant and anxiolytic effects through modulation of reward and emotional...
- Normalises stress-disrupted glutamate transmission, restoring AMPA receptor signalling and NMDA receptor function in the hippocampus and prefrontal cortex
- Reverses stress-induced dendritic atrophy in CA3 hippocampal neurons and restores neurogenesis, directly counteracting the structural brain changes caused...
- Upregulates brain-derived neurotrophic factor expression, supporting neuronal survival, synaptic strengthening, and long-term potentiation critical for...
Where to find it
- Pharmaceutical (Stablon/Coaxil): Available by prescription in France, Russia, India, and over 60 other countries as 12.5 mg tablets
- Tianeptine sodium: Available as a research chemical or supplement in some jurisdictions, typically sold as powder or capsules
- Tianeptine sulfate: An alternative salt form with extended duration, popular in the nootropics community for its smoother pharmacokinetic profile
- Tianeptine free acid: The least common form, with the slowest absorption and longest duration of action
- Quality concerns: When sourcing outside the pharmaceutical supply chain, third-party testing for purity and accurate dosing is essential due to the compound's potency and abuse potential
Frequently asked
An atypical antidepressant with a unique glutamatergic and mu-opioid receptor mechanism that promotes hippocampal neuroplasticity, enhances stress resilience, and improves cognitive function under depressive conditions - prescribed in over 60 countries as Stablon and Coaxil.
The main benefits people report from Tianeptine are: Anxiety & Calm, Cognitive Enhancement, Focus, Memory, Mood, Motivation, Stress Relief.
Standard clinical dosage: 12.5 mg three times daily (37.5 mg total per day), the dose used in virtually all clinical trials and approved prescribing guidelinesSodium form: Tianeptine sodium is the original pharmaceutical form with rapid absorption and shorter duration, requiring three-times-daily do...
Addiction potential: The mu-opioid receptor agonism creates genuine abuse liability, particularly with the sodium form at doses exceeding clinical...Regulatory status: Prescription medication in Europe, Asia, and Latin America. Unscheduled but increasingly regulated in the US - banned in several sta...
Acts as a full agonist at mu-opioid receptors, contributing to its antidepressant and anxiolytic effects through modulation of reward and emotional...Normalises stress-disrupted glutamate transmission, restoring AMPA receptor signalling and NMDA receptor function in the hippocampus and prefrontal co...
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