Nootropic profile
Sunifiram
An AMPAkine compound structurally related to piracetam but estimated to be over 1,000 times more potent - enhances long-term potentiation, AMPA receptor signalling, and memory formation at microgram doses.
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Sunifiram?
Sunifiram (DM-235) is a synthetic AMPAkine nootropic derived from the piperazine backbone, structurally related to piracetam but with dramatically greater potency.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Typical dosage: 5-10 mg taken 1-3 times daily
- Sublingual administration: Often taken sublingually for faster absorption and higher bioavailability
- Start low: Begin with 3-5 mg to assess individual response before increasing
- Cycling recommended: Due to potency and limited long-term safety data, cycling (e.g. 5 days on, 2 days off) is commonly practised
- Onset: Effects typically noticed within 30-60 minutes. Sublingual onset is faster (15-30 minutes)
Watch out for
- Limited human data: No published human clinical trials exist. All efficacy data comes from animal models. Use with caution
- High potency: Due to its extreme potency, precise dosing with a milligram scale is essential. Volumetric dosing in solution is recommended for accuracy
- Overstimulation risk: Excessive doses may cause headache, jaw tension, insomnia, or anxiety due to excessive excitatory signalling
- Not well studied long-term: The long-term safety profile is unknown. Use conservatively and consider cycling
- Not regulated: Sunifiram is not approved as a medicine or food supplement in most jurisdictions. Legal status varies by country
The science, if you're curious.
- Enhances AMPA receptor-mediated excitatory transmission, increasing the speed and strength of synaptic signalling critical for learning
- Facilitates long-term potentiation in hippocampal CA1 neurons via activation of CaMKII (calcium/calmodulin-dependent protein kinase II) and protein kinase C
- Increases glycine binding at the NMDA receptor glycine site, facilitating NMDA-dependent synaptic plasticity
- Stimulates acetylcholine release in the prefrontal cortex, supporting attention and working memory
Where to find it
- Powder: Available from research chemical and specialist nootropic vendors as a powder for precise dosing
- Capsules: Some vendors offer pre-dosed capsules, though these are less common due to the low doses required
- Solution: Volumetric solutions allow more precise measurement of small doses
Frequently asked
An AMPAkine compound structurally related to piracetam but estimated to be over 1,000 times more potent - enhances long-term potentiation, AMPA receptor signalling, and memory formation at microgram doses.
The main benefits people report from Sunifiram are: Cognitive Enhancement, Creativity, Energy, Focus, Memory, Motivation.
Typical dosage: 5-10 mg taken 1-3 times dailySublingual administration: Often taken sublingually for faster absorption and higher bioavailabilityStart low: Begin with 3-5 mg to assess individual response before increasingCycling recommended: Due to potency and limited long-term safety data, cycling...
Limited human data: No published human clinical trials exist. All efficacy data comes from animal models. Use with cautionHigh potency: Due to its extreme potency, precise dosing with a milligram scale is essential. Volumetric dosing in solution is recommended for accuracyOverstimulation risk: Exces...
Enhances AMPA receptor-mediated excitatory transmission, increasing the speed and strength of synaptic signalling critical for learningFacilitates long-term potentiation in hippocampal CA1 neurons via activation of CaMKII (calcium/calmodulin-dependent protein kinase II) and protein kinase CIncreases...
Rate Sunifiram
Log in to leave an overall rating.
What people are saying
Log in to leave a comment.
No comments yet. Be the first to share your experience.