Nootropic profile
Semax
A synthetic peptide derived from adrenocorticotropic hormone (ACTH) developed in Russia as a prescription nootropic that potently increases BDNF levels, enhances focus and memory, and provides neuroprotection.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Semax?
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a heptapeptide analogue of the ACTH(4-10) fragment, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Standard dosage: 200-600 mcg intranasally per day, typically divided into 2-3 doses
- Clinical dosing (Russia): 0.1% nasal solution, 2-3 drops per nostril, 2-3 times daily
- Cycle: Russian prescribing guidelines recommend 10-14 day courses with breaks between cycles
- Onset: Effects on focus and mental clarity may be noticed within hours of intranasal administration
- N-Acetyl Semax Amidate: A modified version with enhanced stability and potency; dosing may differ
Watch out for
- Well tolerated in clinical use: Russian clinical data spanning decades shows a favourable safety profile with minimal side effects
- Possible side effects: Occasional nasal irritation, mild headache, or dizziness
- No hormonal activity: Despite being derived from ACTH, Semax does not affect cortisol production or adrenal function
- Regulatory status: Prescription medication in Russia; not approved by the FDA or MHRA. Available in the UK through research peptide suppliers
- Quality concerns: As an unregulated peptide in Western markets, sourcing from reputable suppliers with third-party testing is essential
The science, if you're curious.
- Increases BDNF gene expression by up to 800% in the hippocampus, supporting neuroplasticity and memory formation
- Increases nerve growth factor expression, supporting neuronal survival and cholinergic system health
- Enhances dopamine and serotonin signalling in the prefrontal cortex and striatum
- Inhibits the enzyme that degrades enkephalins (endogenous opioid peptides), contributing to mood elevation and stress resilience
Where to find it
- Nasal spray: Russian pharmacy-grade Semax 0.1% nasal solution
- Research peptide suppliers: Available from peptide suppliers in lyophilised (freeze-dried) form for reconstitution
- Modified variants: N-Acetyl Semax and N-Acetyl Semax Amidate are enhanced versions with greater stability
Frequently asked
A synthetic peptide derived from adrenocorticotropic hormone (ACTH) developed in Russia as a prescription nootropic that potently increases BDNF levels, enhances focus and memory, and provides neuroprotection.
The main benefits people report from Semax are: Cognitive Enhancement, Focus, Longevity, Memory, Mood, Motivation, Stress Relief.
Standard dosage: 200-600 mcg intranasally per day, typically divided into 2-3 dosesClinical dosing (Russia): 0.1% nasal solution, 2-3 drops per nostril, 2-3 times dailyCycle: Russian prescribing guidelines recommend 10-14 day courses with breaks between cyclesOnset: Effects on focus and mental clari...
Well tolerated in clinical use: Russian clinical data spanning decades shows a favourable safety profile with minimal side effectsPossible side effects: Occasional nasal irritation, mild headache, or dizzinessNo hormonal activity: Despite being derived from ACTH, Semax does not affect cortisol produ...
Increases BDNF gene expression by up to 800% in the hippocampus, supporting neuroplasticity and memory formationIncreases nerve growth factor expression, supporting neuronal survival and cholinergic system healthEnhances dopamine and serotonin signalling in the prefrontal cortex and striatumInhibits...
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