Nootropic profile
Selank
A synthetic peptide analogue of the endogenous immunomodulatory peptide tuftsin, developed in Russia as an anxiolytic and nootropic that modulates GABA and serotonin systems without sedation or dependence.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Selank?
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences - the same laboratory that created Semax.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Standard dosage: 200-600 mcg intranasally per day, divided into 2-3 administrations
- Clinical dosing (Russia): 0.15% nasal solution, 2-3 drops per nostril, 2-3 times daily
- Cycle: Typically used in 14-day cycles with rest periods between courses
- Onset: Anxiolytic effects may be noticed within minutes to hours of intranasal administration
- Combination: Often used alongside Semax in Russian clinical practice - Semax for cognitive enhancement, Selank for anxiety reduction
Watch out for
- Excellent safety profile: Russian clinical data shows minimal side effects even with extended use
- No dependence: Does not produce physical dependence, tolerance, or withdrawal symptoms - a major advantage over benzodiazepines
- No sedation: Anxiolytic effects occur without cognitive impairment or drowsiness
- Regulatory status: Prescription anxiolytic in Russia; not approved by the FDA or MHRA. Available from research peptide suppliers
- Quality concerns: Source from reputable peptide suppliers with certificates of analysis and third-party testing
The science, if you're curious.
- Increases the affinity of GABA for GABA-A receptors and modulates GABA transaminase activity, enhancing inhibitory neurotransmission
- Influences serotonin metabolism and 5-HT receptor sensitivity, contributing to mood-stabilising effects
- Inhibits enkephalin-degrading enzymes, prolonging the activity of endogenous opioid peptides involved in stress resilience and mood
- Increases BDNF in the hippocampus, though to a lesser degree than Semax, supporting memory and neuroplasticity
Where to find it
- Nasal spray: Russian pharmacy-grade Selank 0.15% nasal solution
- Research peptide suppliers: Available in lyophilised form for reconstitution into nasal spray
- Modified variant: N-Acetyl Selank Amidate is an enhanced version with greater stability and potency
Frequently asked
A synthetic peptide analogue of the endogenous immunomodulatory peptide tuftsin, developed in Russia as an anxiolytic and nootropic that modulates GABA and serotonin systems without sedation or dependence.
The main benefits people report from Selank are: Anxiety & Calm, Cognitive Enhancement, Focus, Memory, Mood, Sleep, Stress Relief.
Standard dosage: 200-600 mcg intranasally per day, divided into 2-3 administrationsClinical dosing (Russia): 0.15% nasal solution, 2-3 drops per nostril, 2-3 times dailyCycle: Typically used in 14-day cycles with rest periods between coursesOnset: Anxiolytic effects may be noticed within minutes to...
Excellent safety profile: Russian clinical data shows minimal side effects even with extended useNo dependence: Does not produce physical dependence, tolerance, or withdrawal symptoms - a major advantage over benzodiazepinesNo sedation: Anxiolytic effects occur without cognitive impairment or drowsi...
Increases the affinity of GABA for GABA-A receptors and modulates GABA transaminase activity, enhancing inhibitory neurotransmissionInfluences serotonin metabolism and 5-HT receptor sensitivity, contributing to mood-stabilising effectsInhibits enkephalin-degrading enzymes, prolonging the activity of...
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