Nootropic profile
Quercetin
A powerful bioflavonoid with strong antioxidant, anti-inflammatory, and senolytic properties in the brain - protects against neurodegeneration, reduces neuroinflammation, and supports cerebral blood flow.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Quercetin?
Quercetin is one of the most abundant and well-studied flavonoids in the human diet, found in high concentrations in onions, apples, berries, capers, and green tea.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Standard dosage: 500-1,000 mg per day, typically divided into two doses
- Bioavailability: Quercetin has low oral bioavailability (approximately 2%). Phytosome and liposomal formulations significantly improve absorption
- Enhanced absorption: Taking with fat, vitamin C, or bromelain improves bioavailability. Quercetin phytosome (Quercefit) may increase absorption up to 20-fold
- Timing: Take with meals for better absorption. Divide into morning and evening doses
- Onset: Antioxidant effects occur acutely. Anti-inflammatory and neuroprotective benefits build over weeks of consistent supplementation
Watch out for
- Generally safe: Quercetin is a natural dietary component with extensive history of safe consumption in foods
- High-dose caution: Doses above 1,000 mg/day may cause headache, tingling, or mild kidney stress in susceptible individuals
- Drug interactions: Inhibits CYP3A4 and CYP2C8 enzymes. May increase blood levels of certain medications including cyclosporine, some statins, and calcium...
- Thyroid: High-dose quercetin may inhibit thyroid peroxidase. Individuals with hypothyroidism should monitor thyroid function
- Anticoagulant interaction: Quercetin may enhance the effects of blood-thinning medications. Use with caution and medical supervision
The science, if you're curious.
- Activates the Nrf2 antioxidant pathway, upregulating endogenous antioxidant enzymes (glutathione, SOD, catalase) to protect neurons from oxidative stress
- Suppresses NF-kB-mediated inflammatory signalling, reducing neuroinflammation and microglial overactivation
- Particularly when combined with dasatinib, clears senescent cells that accumulate in the ageing brain and secrete pro-inflammatory factors
- Inhibits monoamine oxidase A, slowing the breakdown of serotonin and norepinephrine and supporting mood
Where to find it
- Quercetin capsules: Standard quercetin dihydrate or anhydrous forms, widely available in 250-500 mg capsules
- Quercetin phytosome: Lipid-bound formulation (e.g. Quercefit by Indena) with dramatically improved bioavailability
- Liposomal quercetin: Liposomal encapsulation for enhanced absorption
- Food sources: Capers (richest source), red onions, apples (with skin), berries, green tea, dark cherries, and buckwheat
Frequently asked
A powerful bioflavonoid with strong antioxidant, anti-inflammatory, and senolytic properties in the brain - protects against neurodegeneration, reduces neuroinflammation, and supports cerebral blood flow.
The main benefits people report from Quercetin are: Cognitive Enhancement, Energy, Longevity, Memory, Mood, Stress Relief.
Standard dosage: 500-1,000 mg per day, typically divided into two dosesBioavailability: Quercetin has low oral bioavailability (approximately 2%). Phytosome and liposomal formulations significantly improve absorptionEnhanced absorption: Taking with fat, vitamin C, or bromelain improves bioavailabili...
Generally safe: Quercetin is a natural dietary component with extensive history of safe consumption in foodsHigh-dose caution: Doses above 1,000 mg/day may cause headache, tingling, or mild kidney stress in susceptible individualsDrug interactions: Inhibits CYP3A4 and CYP2C8 enzymes. May increase bl...
Activates the Nrf2 antioxidant pathway, upregulating endogenous antioxidant enzymes (glutathione, SOD, catalase) to protect neurons from oxidative stressSuppresses NF-kB-mediated inflammatory signalling, reducing neuroinflammation and microglial overactivationParticularly when combined with dasatini...
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