Nootropic profile
Phenylpiracetam Hydrazide
Also known as Fonturacetam, a derivative of phenylpiracetam where the amide group is replaced with a hydrazide - offering similar dopaminergic and glutamatergic cognitive enhancement with a potentially distinct receptor affinity profile, developed as phenylpiracetam became harder to source.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Phenylpiracetam Hydrazide?
Phenylpiracetam hydrazide (also known as Fonturacetam hydrazide) is a structural analogue of phenylpiracetam (Phenotropil) in which the terminal amide group (-CONH2) of the piracetam backbone is replaced with a hydrazide group (-CONHNH2).
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Typical dose: 50-100 mg per day, similar to standard phenylpiracetam dosing, taken in the morning or early afternoon
- Starting dose: 50 mg to assess individual response, as sensitivity varies considerably between individuals
- Maximum daily dose: 200 mg per day (often split into two 100 mg doses), though most users find 50-100 mg sufficient
- Timing: Best taken in the morning or early afternoon due to stimulatory effects. Avoid evening dosing to prevent insomnia
- Cycling: Like phenylpiracetam, tolerance may develop with daily use. Common cycling protocols include 3-4 days on and 3-4 days off, or use only on...
Watch out for
- Limited research: No published clinical trials exist specifically for phenylpiracetam hydrazide. Safety is inferred from phenylpiracetam research and...
- Expected side effects: Based on phenylpiracetam data, potential side effects include insomnia, irritability, headache, and overstimulation, particularly at...
- Tolerance development: Tolerance to the stimulatory and cognitive-enhancing effects is commonly reported with daily use, necessitating cycling protocols
- WADA banned substance: Phenylpiracetam is on the World Anti-Doping Agency prohibited list. Athletes should be aware that the hydrazide derivative may...
- Drug interactions: Use caution when combining with other stimulants, dopaminergic agents, or racetams. Avoid stacking with MAO inhibitors due to potential...
The science, if you're curious.
- Like phenylpiracetam, expected to increase dopamine receptor density (D1, D2, D3) in the striatum with repeated use, enhancing motivation, reward...
- Binds to nicotinic acetylcholine receptors, supporting attentional processes, working memory, and the speed of information processing
- Modulates AMPA and NMDA receptor signalling, facilitating long-term potentiation and synaptic plasticity underlying learning and memory consolidation
- Provides mild stimulatory effects without the jitteriness of traditional stimulants, likely through combined dopaminergic and noradrenergic modulation...
Where to find it
- Nootropic vendors: Widely available from nootropic supplement companies as capsules or powder, typically in 50 mg or 100 mg units
- Powder form: Available as a water-soluble powder suitable for precise dosing with a milligram scale
- No pharmaceutical production: Unlike original phenylpiracetam (which was manufactured as Phenotropil), the hydrazide derivative has never been produced by a pharmaceutical company
- Quality variation: As an unregulated compound, quality and purity vary between vendors. Third-party certificates of analysis should be verified before purchase
Frequently asked
Also known as Fonturacetam, a derivative of phenylpiracetam where the amide group is replaced with a hydrazide - offering similar dopaminergic and glutamatergic cognitive enhancement with a potentially distinct receptor affinity profile, developed as phenylpiracetam became harder to source.
The main benefits people report from Phenylpiracetam Hydrazide are: Cognitive Enhancement, Creativity, Energy, Focus, Memory, Mood, Motivation.
Typical dose: 50-100 mg per day, similar to standard phenylpiracetam dosing, taken in the morning or early afternoonStarting dose: 50 mg to assess individual response, as sensitivity varies considerably between individualsMaximum daily dose: 200 mg per day (often split into two 100 mg doses), though...
Limited research: No published clinical trials exist specifically for phenylpiracetam hydrazide. Safety is inferred from phenylpiracetam research and...Expected side effects: Based on phenylpiracetam data, potential side effects include insomnia, irritability, headache, and overstimulation, particul...
Like phenylpiracetam, expected to increase dopamine receptor density (D1, D2, D3) in the striatum with repeated use, enhancing motivation, reward...Binds to nicotinic acetylcholine receptors, supporting attentional processes, working memory, and the speed of information processingModulates AMPA and...
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