Nootropic profile
Oxiracetam
Oxiracetam is a synthetic racetam nootropic known for its mildly stimulating cognitive effects. It is one of the more potent members of the racetam family, particularly valued for enhancing memory formation, logical thinking, and verbal fluency without the jitteriness associated with traditional stimulants.
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Oxiracetam?
Oxiracetam is a synthetic derivative of piracetam (the original racetam), developed in the 1970s by ICF, an Italian pharmaceutical company.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Typical dose: 800-2400 mg per day, divided into 2-3 doses
- Common protocol: 800 mg taken 2-3 times daily (1600-2400 mg total)
- Starting dose: 400-800 mg to assess individual response
- Timing: Best taken earlier in the day due to mild stimulatory effects. Avoid evening dosing to prevent sleep disruption.
- Choline pairing: Often stacked with a choline source (Alpha-GPC or citicoline) to support increased acetylcholine demand and prevent potential headaches
Watch out for
- Side effects: Generally well tolerated. Most commonly reported: headache (often mitigated by choline supplementation), mild insomnia if taken late in the...
- Regulatory status: Not approved as a pharmaceutical in most Western countries (unregulated/grey market). Prescription drug in some European countries. Not...
- Drug interactions: May interact with cholinergic drugs and carbamazepine. Consult a doctor if taking any medications.
- Pregnancy: No safety data available. Avoid during pregnancy and breastfeeding.
- Kidney function: Primarily excreted unchanged by the kidneys. Those with impaired kidney function should use with caution and medical supervision.
The science, if you're curious.
- Oxiracetam enhances acetylcholine utilisation and may increase acetylcholine release in the hippocampus and cortex, brain regions critical for memory...
- It modulates AMPA and NMDA glutamate receptors, enhancing excitatory neurotransmission essential for long-term potentiation (LTP) and synaptic plasticity.
- Oxiracetam activates protein kinase C (PKC) in the hippocampus, an enzyme involved in memory consolidation and the strengthening of synaptic connections.
- It may increase levels of D-Aspartic acid in the brain, which serves as an agonist at NMDA receptors and supports learning processes.
Where to find it
- Synthetic compound: Oxiracetam does not occur naturally and must be synthesised in a laboratory
- Bulk powder: The most common and cost-effective form, available from nootropic vendors
- Capsules: Pre-measured doses available from various supplement companies
- Pharmaceutical grade: Marketed as Neuromet in Italy, though availability varies by country
- Quality note: Purchase from vendors that provide third-party certificates of analysis (CoA) to verify purity and identity
Frequently asked
Oxiracetam is a synthetic racetam nootropic known for its mildly stimulating cognitive effects. It is one of the more potent members of the racetam family, particularly valued for enhancing memory formation, logical thinking, and verbal fluency without the jitteriness associated with traditional stimulants.
The main benefits people report from Oxiracetam are: Cognitive Enhancement, Creativity, Energy, Focus, Memory, Motivation.
Typical dose: 800-2400 mg per day, divided into 2-3 dosesCommon protocol: 800 mg taken 2-3 times daily (1600-2400 mg total)Starting dose: 400-800 mg to assess individual responseTiming: Best taken earlier in the day due to mild stimulatory effects. Avoid evening dosing to prevent sleep disruption.Ch...
Side effects: Generally well tolerated. Most commonly reported: headache (often mitigated by choline supplementation), mild insomnia if taken late in the...Regulatory status: Not approved as a pharmaceutical in most Western countries (unregulated/grey market). Prescription drug in some European coun...
Oxiracetam enhances acetylcholine utilisation and may increase acetylcholine release in the hippocampus and cortex, brain regions critical for memory...It modulates AMPA and NMDA glutamate receptors, enhancing excitatory neurotransmission essential for long-term potentiation (LTP) and synaptic plast...
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