Nootropic profile
Noopept
Noopept is a potent synthetic peptide-derived nootropic developed in Russia, often described as up to 1,000 times more potent than piracetam by weight. It enhances memory, learning, focus, and neuroprotection at very low doses.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Noopept?
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, also known as GVS-111 or Omberacetam) is a synthetic nootropic peptide developed in the 1990s at the Russian Academy of Medical Sciences.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Typical dose: 10–30 mg per day, divided into 2–3 doses
- Starting dose: 10 mg, taken sublingually or orally
- Sublingual administration: Placing powder under the tongue improves absorption and speeds onset
- Cycle: Often cycled - 56 days on, 4 days off (following the original Russian clinical protocol)
- Onset: Effects typically felt within 15–20 minutes
Watch out for
- Side effects: Generally well-tolerated. Some users report headaches, irritability, or insomnia at higher doses.
- Toxicity: Low. Animal studies show a wide safety margin.
- Headaches: As with racetams, headaches may indicate choline depletion - stacking with Alpha-GPC or citicoline can help.
- Overstimulation: Some users report feeling overstimulated or anxious at doses above 30 mg.
- Legal status: Available over-the-counter in Russia. Sold as a research chemical or supplement in the US and UK - not FDA-approved.
The science, if you're curious.
- Noopept increases expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), proteins essential for neuronal growth, survival,...
- Enhances AMPA and NMDA receptor signalling, supporting long-term potentiation (LTP) - the cellular basis of learning and memory.
- Increases sensitivity of acetylcholine receptors rather than directly increasing acetylcholine levels, supporting memory and attention.
- Provides neuroprotection by reducing oxidative stress and inhibiting calcium overload in neurons, particularly under conditions of excitotoxicity.
Where to find it
- Synthetic compound: Does not occur in nature - must be synthesised
- Supplement form: Available as capsules, powder, and sublingual tablets from nootropic vendors
- Brand name: Noopept (Russia) - sold as an over-the-counter cognitive enhancer
The research
Frequently asked
Noopept is a potent synthetic peptide-derived nootropic developed in Russia, often described as up to 1,000 times more potent than piracetam by weight. It enhances memory, learning, focus, and neuroprotection at very low doses.
The main benefits people report from Noopept are: Anxiety & Calm, Cognitive Enhancement, Creativity, Focus, Longevity, Memory.
Typical dose: 10–30 mg per day, divided into 2–3 dosesStarting dose: 10 mg, taken sublingually or orallySublingual administration: Placing powder under the tongue improves absorption and speeds onsetCycle: Often cycled - 56 days on, 4 days off (following the original Russian clinical protocol)Onset:...
Side effects: Generally well-tolerated. Some users report headaches, irritability, or insomnia at higher doses.Toxicity: Low. Animal studies show a wide safety margin.Headaches: As with racetams, headaches may indicate choline depletion - stacking with Alpha-GPC or citicoline can help.Overstimulatio...
Noopept increases expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), proteins essential for neuronal growth, survival,...Enhances AMPA and NMDA receptor signalling, supporting long-term potentiation (LTP) - the cellular basis of learning and memory.Increases sensit...
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