Nootropic profile
Nefiracetam
Nefiracetam is a fat-soluble synthetic racetam developed in Japan that modulates multiple neurotransmitter systems including cholinergic, GABAergic, and glutamatergic pathways. It has been investigated for age-related cognitive decline and shows particular promise for long-term memory enhancement.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Nefiracetam?
Nefiracetam (N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide, also known as DM-9384) was developed by Daiichi Pharmaceutical Company in Japan as a follow-up to piracetam and aniracetam.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Typical dose: 100-900 mg per day, divided into 2-3 doses
- Common protocol: 150-300 mg taken 2-3 times daily
- Clinical trials: Used doses of 150-450 mg three times daily (450-1350 mg/day total)
- Fat-soluble: Take with a fat-containing meal or fat supplement for optimal absorption
- Timing: Divide doses evenly throughout the day for consistent blood levels
Watch out for
- Testicular toxicity: Long-term animal studies at high doses (300 mg/kg/day in dogs) showed testicular toxicity. This was a major factor in discontinuing...
- Discontinued development: Nefiracetam is no longer being actively developed as a pharmaceutical, meaning safety data from large-scale trials is limited.
- Side effects: Generally well tolerated in completed clinical trials. Reported side effects include headache, nausea, dizziness, and GI discomfort.
- Regulatory status: Not approved as a pharmaceutical anywhere. Available as an unregulated research compound in most countries.
- Male reproductive concern: Males should be particularly cautious given the animal testicular toxicity data. Long-term use is not recommended.
The science, if you're curious.
- Nefiracetam potentiates nicotinic acetylcholine receptor (nAChR) activity and enhances acetylcholine release in the hippocampus, supporting memory formation...
- It prolongs the opening of GABA-A receptor chloride channels without affecting the binding of GABA itself, producing a unique modulatory effect that may...
- Nefiracetam potentiates NMDA receptor currents and may enhance long-term potentiation (LTP), the synaptic strengthening process underlying memory consolidation.
- Activates PKC and CaM kinase II in the hippocampus, enzymes involved in synaptic plasticity and memory formation.
Where to find it
- Synthetic compound: Nefiracetam does not occur naturally and must be synthesised
- Bulk powder: Available from specialty nootropic vendors
- Capsules: Some vendors offer pre-measured capsules
- Quality note: As with all synthetic nootropics, third-party certificates of analysis are essential for verifying purity and identity
Frequently asked
Nefiracetam is a fat-soluble synthetic racetam developed in Japan that modulates multiple neurotransmitter systems including cholinergic, GABAergic, and glutamatergic pathways. It has been investigated for age-related cognitive decline and shows particular promise for long-term memory enhancement.
The main benefits people report from Nefiracetam are: Anxiety & Calm, Cognitive Enhancement, Focus, Memory, Mood, Motivation.
Typical dose: 100-900 mg per day, divided into 2-3 dosesCommon protocol: 150-300 mg taken 2-3 times dailyClinical trials: Used doses of 150-450 mg three times daily (450-1350 mg/day total)Fat-soluble: Take with a fat-containing meal or fat supplement for optimal absorptionTiming: Divide doses evenly...
Testicular toxicity: Long-term animal studies at high doses (300 mg/kg/day in dogs) showed testicular toxicity. This was a major factor in discontinuing...Discontinued development: Nefiracetam is no longer being actively developed as a pharmaceutical, meaning safety data from large-scale trials is l...
Nefiracetam potentiates nicotinic acetylcholine receptor (nAChR) activity and enhances acetylcholine release in the hippocampus, supporting memory formation...It prolongs the opening of GABA-A receptor chloride channels without affecting the binding of GABA itself, producing a unique modulatory effe...
Rate Nefiracetam
Log in to leave an overall rating.
What people are saying
Log in to leave a comment.
No comments yet. Be the first to share your experience.