Nootropic profile
Idebenone
A synthetic analogue of CoQ10 engineered to cross the blood-brain barrier more effectively - provides superior mitochondrial support and neuroprotection compared to its parent compound.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Idebenone?
Idebenone (2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione) is a synthetic short-chain benzoquinone structurally related to Coenzyme Q10 (CoQ10) but specifically engineered with a shorter lipophilic tail that dramatically improves its.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Nootropic dosage: 150-300 mg per day, divided into 2-3 doses taken with meals containing fat
- Clinical dosage (LHON): 900 mg per day (prescription Raxone)
- Alzheimer's trial dosage: 270-360 mg per day in divided doses
- Bioavailability: Fat-soluble. Always take with a meal containing dietary fat for optimal absorption
- Onset: Mitochondrial effects begin acutely. Cognitive benefits typically noticed after 2-4 weeks of consistent supplementation
Watch out for
- Generally well tolerated: Clinical trials at doses up to 900 mg/day report a favourable safety profile with mild and transient side effects
- GI effects: Nausea, diarrhoea, and mild stomach discomfort are the most common side effects, usually dose-dependent and transient
- Prooxidant potential: Unlike CoQ10, idebenone may act as a prooxidant under certain conditions (when fully reduced in the presence of Complex I inhibition)....
- Drug interactions: May interact with anticoagulant medications (warfarin) as it shares structural similarity with vitamin K. Monitor INR if combining
- Pregnancy: Insufficient safety data for use during pregnancy or breastfeeding
The science, if you're curious.
- Shuttles electrons in the electron transport chain, bypassing Complex I dysfunction to maintain ATP production in compromised mitochondria
- Its shorter lipophilic tail (compared to CoQ10) allows efficient crossing of the blood-brain barrier, concentrating in neural tissue
- Scavenges lipid peroxyl radicals, protecting mitochondrial and neuronal membranes from oxidative chain reactions
- Stimulates NGF production, supporting neuronal survival, growth, and synaptic maintenance
Where to find it
- Capsules: Available from nootropic retailers in 45 mg, 100 mg, and 150 mg capsules
- Prescription (Raxone): 150 mg tablets prescribed for LHON in Europe
- Powder: Bulk powder available from research chemical suppliers for precise dosing
Frequently asked
A synthetic analogue of CoQ10 engineered to cross the blood-brain barrier more effectively - provides superior mitochondrial support and neuroprotection compared to its parent compound.
The main benefits people report from Idebenone are: Cognitive Enhancement, Energy, Focus, Longevity, Memory, Mood.
Nootropic dosage: 150-300 mg per day, divided into 2-3 doses taken with meals containing fatClinical dosage (LHON): 900 mg per day (prescription Raxone)Alzheimer's trial dosage: 270-360 mg per day in divided dosesBioavailability: Fat-soluble. Always take with a meal containing dietary fat for o...
Generally well tolerated: Clinical trials at doses up to 900 mg/day report a favourable safety profile with mild and transient side effectsGI effects: Nausea, diarrhoea, and mild stomach discomfort are the most common side effects, usually dose-dependent and transientProoxidant potential: Unlike CoQ...
Shuttles electrons in the electron transport chain, bypassing Complex I dysfunction to maintain ATP production in compromised mitochondriaIts shorter lipophilic tail (compared to CoQ10) allows efficient crossing of the blood-brain barrier, concentrating in neural tissueScavenges lipid peroxyl radica...
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