Nootropic profile
Hydergine (Ergoloid Mesylates)
One of the oldest and most studied nootropic drugs - a mixture of ergot alkaloids developed in the 1940s that enhances cerebral blood flow, neuronal metabolism, and has been prescribed for cognitive decline for decades.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Hydergine (Ergoloid Mesylates)?
Hydergine (ergoloid mesylates) is a mixture of dihydrogenated ergot alkaloids developed by Albert Hofmann - the same chemist who discovered LSD - at Sandoz Laboratories in 1949.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Standard dosage: 3-6 mg per day, divided into 3 doses taken with meals
- Nootropic community dosage: Some users take up to 9-12 mg per day, though this exceeds standard clinical recommendations
- Clinical dosage: FDA-approved dosage was 3 mg per day in divided doses for age-related cognitive decline
- Sublingual: Some users dissolve tablets sublingually for faster absorption, though this is not the standard route
- Onset: Acute effects on alertness within 1-2 hours. Full cognitive benefits develop over 4-12 weeks of consistent use
Watch out for
- Decades of clinical safety: Prescribed to millions of patients worldwide since the 1950s with an excellent safety record
- Mild side effects: Occasional nausea, headache, dizziness, and mild GI discomfort. Generally very well tolerated
- Hypotension: May lower blood pressure due to alpha-adrenergic blocking effects. Use caution in individuals with low blood pressure or those taking...
- Ergot sensitivity: Contraindicated in individuals with known ergot alkaloid sensitivity or allergy
- Availability: Prescription medication in many countries. Availability has decreased as newer dementia drugs have taken its place. Generic versions exist
The science, if you're curious.
- Improves oxygen delivery and glucose utilisation in the brain by dilating cerebral blood vessels and improving microcirculation
- Directly neutralises superoxide and hydroxyl radicals, protecting neuronal membranes from oxidative damage
- Partial agonist at dopamine D2 receptors, enhancing dopaminergic transmission in the prefrontal cortex
- Partial agonist at serotonin 5-HT2A receptors, contributing to mood enhancement and neuroplasticity
Where to find it
- Prescription tablets: Available as generic ergoloid mesylates in 1 mg tablets (take 3 per day for standard dosage)
- Brand names: Hydergine (Novartis), though brand-name availability varies by country
- International pharmacies: Available from international online pharmacies in countries where it remains marketed
Frequently asked
One of the oldest and most studied nootropic drugs - a mixture of ergot alkaloids developed in the 1940s that enhances cerebral blood flow, neuronal metabolism, and has been prescribed for cognitive decline for decades.
The main benefits people report from Hydergine (Ergoloid Mesylates) are: Cognitive Enhancement, Energy, Focus, Longevity, Memory, Mood.
Standard dosage: 3-6 mg per day, divided into 3 doses taken with mealsNootropic community dosage: Some users take up to 9-12 mg per day, though this exceeds standard clinical recommendationsClinical dosage: FDA-approved dosage was 3 mg per day in divided doses for age-related cognitive declineSublin...
Decades of clinical safety: Prescribed to millions of patients worldwide since the 1950s with an excellent safety recordMild side effects: Occasional nausea, headache, dizziness, and mild GI discomfort. Generally very well toleratedHypotension: May lower blood pressure due to alpha-adrenergic blocki...
Improves oxygen delivery and glucose utilisation in the brain by dilating cerebral blood vessels and improving microcirculationDirectly neutralises superoxide and hydroxyl radicals, protecting neuronal membranes from oxidative damagePartial agonist at dopamine D2 receptors, enhancing dopaminergic tr...
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