Nootropic profile
Flmodafinil
Also known as CRL-40,940 or bisfluoromodafinil, a bisfluoro analogue of modafinil with fluorine atoms at para positions - offering potentially higher bioavailability and longer duration through dopamine reuptake inhibition, histamine modulation, and orexin system activation at lower doses than its parent compound.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Flmodafinil?
Flmodafinil (CRL-40,940, bisfluoromodafinil, lauflumide) is a synthetic eugeroic compound structurally derived from modafinil by the addition of two fluorine atoms at the para positions of the diphenylmethyl sulfinyl backbone.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Typical dose: 50-100 mg per day, approximately 50-75% of the equivalent modafinil dose due to reportedly higher potency
- Starting dose: 50 mg in the morning to assess individual response before considering dose increases
- Duration of effects: Anecdotal reports suggest 10-15 hours of wakefulness-promoting effects, potentially longer than standard modafinil
- Timing: Take in the morning or early afternoon only. The extended duration means that afternoon dosing is likely to cause significant sleep disruption
- Frequency: Typically used 2-4 days per week rather than daily, both to prevent tolerance and to avoid chronic sleep architecture disruption
Watch out for
- No clinical safety data: Flmodafinil has never undergone formal human safety testing, clinical trials, or regulatory review. All safety information is...
- Expected side effect profile: Based on modafinil pharmacology, likely side effects include headache, nausea, insomnia, anxiety, dry mouth, and reduced...
- Cardiovascular considerations: Modafinil-class compounds can elevate heart rate and blood pressure. Individuals with cardiovascular conditions should...
- Drug interactions: Likely induces CYP3A4 enzyme activity (as modafinil does), potentially reducing the effectiveness of hormonal contraceptives,...
- Regulatory uncertainty: Currently unscheduled in most countries, but this status may change. The US FDA and equivalent agencies in other countries have not...
The science, if you're curious.
- Like modafinil, inhibits the dopamine transporter (DAT), increasing extracellular dopamine concentrations in the prefrontal cortex, nucleus accumbens, and...
- Increases histamine release in the tuberomammillary nucleus, promoting wakefulness and cortical arousal through H1 receptor stimulation in the cortex and...
- Activates orexin-producing neurons in the lateral hypothalamus, reinforcing the wake-promoting signal and stabilising the sleep-wake transition - the same...
- Increases norepinephrine release in the prefrontal cortex and locus coeruleus, supporting alertness, attention, and working memory capacity
Where to find it
- Nootropic vendors: Available from research chemical and nootropic supplement companies as capsules, tablets, or powder
- Powder form: Available as a crystalline powder for those who prefer to prepare their own doses with precise measurement
- Capsule form: Pre-dosed capsules (typically 50 mg or 100 mg) are the most convenient and commonly purchased form
- No pharmaceutical production: Flmodafinil has never been commercially manufactured by a pharmaceutical company and exists solely as a research chemical or nootropic supplement
- Quality considerations: As with all unregulated compounds, verify third-party testing certificates and purchase from reputable vendors with transparent analytical testing
Frequently asked
Also known as CRL-40,940 or bisfluoromodafinil, a bisfluoro analogue of modafinil with fluorine atoms at para positions - offering potentially higher bioavailability and longer duration through dopamine reuptake inhibition, histamine modulation, and orexin system activation at lower doses than its parent compound.
The main benefits people report from Flmodafinil are: Cognitive Enhancement, Creativity, Energy, Focus, Memory, Mood, Motivation.
Typical dose: 50-100 mg per day, approximately 50-75% of the equivalent modafinil dose due to reportedly higher potencyStarting dose: 50 mg in the morning to assess individual response before considering dose increasesDuration of effects: Anecdotal reports suggest 10-15 hours of wakefulness-promotin...
No clinical safety data: Flmodafinil has never undergone formal human safety testing, clinical trials, or regulatory review. All safety information is...Expected side effect profile: Based on modafinil pharmacology, likely side effects include headache, nausea, insomnia, anxiety, dry mouth, and redu...
Like modafinil, inhibits the dopamine transporter (DAT), increasing extracellular dopamine concentrations in the prefrontal cortex, nucleus accumbens, and...Increases histamine release in the tuberomammillary nucleus, promoting wakefulness and cortical arousal through H1 receptor stimulation in the...
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