Nootropic profile
Fisetin
A flavonoid found in strawberries with potent senolytic, anti-inflammatory, and neuroprotective properties - shown to clear senescent cells, support long-term potentiation for memory, and protect against age-related cognitive decline.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Fisetin?
Fisetin (3,3',4',7-tetrahydroxyflavone) is a naturally occurring flavonoid found in highest concentrations in strawberries, with smaller amounts in apples, persimmons, grapes, onions, and cucumbers.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Daily neuroprotective dosage: 100-500 mg per day
- Senolytic protocol: Some longevity researchers suggest intermittent high-dose protocols (e.g. 500-1,000 mg for 2 consecutive days per month), though human...
- Bioavailability: Fisetin has low oral bioavailability. Liposomal formulations or taking with a fat source may improve absorption
- Food sources: Strawberries are the richest dietary source (approximately 160 mcg/g), but you would need to eat several kilograms daily to reach supplement doses
- Onset: Antioxidant and anti-inflammatory effects occur with daily use. Senolytic benefits are measured over months
Watch out for
- Generally well tolerated: Fisetin has a long history of dietary exposure through fruit consumption and limited adverse effects in studies
- Limited human trial data: While animal and in vitro data are extensive, large-scale human trials specifically for fisetin are ongoing (Mayo Clinic AFFIRM...
- Potential drug interactions: May inhibit CYP450 enzymes at high doses. Consult your doctor if taking medications with narrow therapeutic windows
- Anticoagulant interaction: Theoretical interaction with blood-thinning medications. Use caution and consult your doctor
- Pregnancy and breastfeeding: Insufficient data for supplement-dose fisetin. Dietary intake from fruit is safe
The science, if you're curious.
- Selectively induces apoptosis in senescent cells - dysfunctional cells that accumulate with age and secrete pro-inflammatory factors (SASP) that damage...
- Facilitates LTP in hippocampal neurons via ERK/CREB signalling pathway activation, directly supporting memory formation
- Activates the Nrf2 antioxidant pathway, upregulating glutathione synthesis and endogenous antioxidant enzyme production
- Suppresses inflammatory signalling, reducing neuroinflammation and microglial overactivation
Where to find it
- Capsules: Available from longevity and nootropic supplement retailers in 100-500 mg capsules
- Liposomal formulations: Enhanced bioavailability formulations using liposomal delivery
- Food sources: Strawberries (richest source), apples, persimmons, grapes, onions, mangoes, kiwi, and cucumbers
Frequently asked
A flavonoid found in strawberries with potent senolytic, anti-inflammatory, and neuroprotective properties - shown to clear senescent cells, support long-term potentiation for memory, and protect against age-related cognitive decline.
The main benefits people report from Fisetin are: Cognitive Enhancement, Focus, Longevity, Memory, Mood, Stress Relief.
Daily neuroprotective dosage: 100-500 mg per daySenolytic protocol: Some longevity researchers suggest intermittent high-dose protocols (e.g. 500-1,000 mg for 2 consecutive days per month), though human...Bioavailability: Fisetin has low oral bioavailability. Liposomal formulations or taking with a...
Generally well tolerated: Fisetin has a long history of dietary exposure through fruit consumption and limited adverse effects in studiesLimited human trial data: While animal and in vitro data are extensive, large-scale human trials specifically for fisetin are ongoing (Mayo Clinic AFFIRM...Potenti...
Selectively induces apoptosis in senescent cells - dysfunctional cells that accumulate with age and secrete pro-inflammatory factors (SASP) that damage...Facilitates LTP in hippocampal neurons via ERK/CREB signalling pathway activation, directly supporting memory formationActivates the Nrf2 antioxid...
Rate Fisetin
Log in to leave an overall rating.
What people are saying
Log in to leave a comment.
No comments yet. Be the first to share your experience.