Nootropic profile
Fasoracetam
A newer-generation racetam that uniquely upregulates GABA-B receptors and enhances high-affinity choline uptake, researched for ADHD, anxiety, and cognitive support with a distinct mechanism from other racetams.
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Fasoracetam?
Fasoracetam (NS-105, LAM-105) is a synthetic nootropic of the racetam family, originally developed by the Japanese pharmaceutical company Nippon Shinyaku in the 1990s for the treatment of vascular dementia.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Nootropic dosage: 20-100 mg per day, taken sublingually or orally
- Clinical trial dosage (ADHD): 100-400 mg twice daily was used in the Aevi Technologies Phase II trials
- Sublingual administration: Many users report better effects when taken sublingually rather than swallowed, due to improved bioavailability
- Timing: Can be taken once or twice daily. Some users prefer morning dosing for focus effects
- Onset: Effects on focus and mental clarity may be noticed within 1-2 hours. GABA-B receptor upregulation effects develop over days to weeks
Watch out for
- Generally well tolerated: The ADHD clinical trials reported a favourable safety profile with no serious adverse events
- Possible side effects: Headache, fatigue, or gastrointestinal discomfort at higher doses
- Choline support: As with other racetams that enhance cholinergic function, supplementing with a choline source (citicoline, Alpha-GPC) may reduce headache risk
- Regulatory status: Not approved as a medication in any country. Available as an unregulated compound from nootropic suppliers
- Limited long-term data: While the ADHD trials provided useful safety data, long-term safety for nootropic use is not fully established
The science, if you're curious.
- Increases the density and sensitivity of GABA-B receptors, restoring GABAergic tone - particularly relevant after GABA-B agonist (phenibut, baclofen) use
- Enhances the transport of choline into cholinergic neurons, increasing acetylcholine synthesis capacity
- Influences mGluR signalling, which is relevant to the ADHD subtype with mGluR network gene variants
- May increase cAMP levels in cortical neurons, supporting intracellular signalling cascades involved in memory
Where to find it
- Powder: Available from nootropic retailers in powder form, typically with a small scoop for dosing
- Capsules: Some suppliers offer pre-capsulated fasoracetam in 20-100 mg doses
- Solution: Sublingual solutions available from research chemical suppliers
Frequently asked
A newer-generation racetam that uniquely upregulates GABA-B receptors and enhances high-affinity choline uptake, researched for ADHD, anxiety, and cognitive support with a distinct mechanism from other racetams.
The main benefits people report from Fasoracetam are: Anxiety & Calm, Cognitive Enhancement, Focus, Memory, Mood, Motivation.
Nootropic dosage: 20-100 mg per day, taken sublingually or orallyClinical trial dosage (ADHD): 100-400 mg twice daily was used in the Aevi Technologies Phase II trialsSublingual administration: Many users report better effects when taken sublingually rather than swallowed, due to improved bioavailab...
Generally well tolerated: The ADHD clinical trials reported a favourable safety profile with no serious adverse eventsPossible side effects: Headache, fatigue, or gastrointestinal discomfort at higher dosesCholine support: As with other racetams that enhance cholinergic function, supplementing with...
Increases the density and sensitivity of GABA-B receptors, restoring GABAergic tone - particularly relevant after GABA-B agonist (phenibut, baclofen) useEnhances the transport of choline into cholinergic neurons, increasing acetylcholine synthesis capacityInfluences mGluR signalling, which is releva...
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