Nootropic profile
Dihexa
A hexapeptide analogue of angiotensin IV developed at Washington State University that is 10 million times more potent than BDNF at promoting synaptogenesis - crossing the blood-brain barrier orally and reversing cognitive deficits in aged animal models through dramatic increases in dendritic spine density.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Dihexa?
Dihexa (N-hexanoic-Tyr-Ile-(6)aminohexanoic amide) is a synthetic hexapeptide derived from the hepatocyte growth factor (HGF) system, originally developed by Dr. Joseph Harding and colleagues at Washington State University.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Animal research doses: In rat studies, effective doses ranged from 0.01 to 2 mg/kg administered orally, intranasally, or intracerebroventricularly
- Community-reported oral dose: 10-20 mg per day is the most commonly reported oral dose among early adopters in the nootropics community, though this is...
- Intranasal use: Some users report intranasal administration at lower doses (2-5 mg) for potentially improved CNS delivery, though no human pharmacokinetic...
- Picomolar potency: The extraordinary potency of dihexa at the molecular level means that effective brain concentrations are achieved at relatively low oral...
- Duration of use: Most community protocols involve short courses (2-4 weeks) followed by extended breaks, given the lack of long-term safety data and...
Watch out for
- No human safety data: Dihexa has never been tested in human clinical trials. All safety information is extrapolated from animal studies and anecdotal...
- Theoretical cancer risk: The HGF/c-Met pathway is frequently overactivated in various cancers. Chronic exogenous activation of this growth factor system...
- Unknown long-term effects: The consequences of sustained exogenous synaptogenesis and growth factor stimulation in the human brain are completely unknown....
- Purity concerns: As an unregulated research peptide, quality control varies dramatically between sources. Impurities in peptide synthesis could pose...
- Not recommended for individuals with: Any history of cancer, family history of cancer, or conditions involving abnormal cell growth. The growth-promoting...
The science, if you're curious.
- Dihexa binds to hepatocyte growth factor (HGF) and facilitates its dimerisation, activating the c-Met receptor tyrosine kinase and triggering procognitive...
- Activates PI3K/Akt and MAPK/ERK pathways downstream of c-Met, stimulating the formation of new synaptic connections between neurons at a potency...
- Increases dendritic spine density in hippocampal and cortical neurons, expanding the physical substrate for synaptic transmission and information storage
- The HGF/c-Met axis activates anti-apoptotic pathways including Bcl-2 upregulation, protecting existing neurons from programmed cell death and age-related...
Where to find it
- Research peptide vendors: Available from specialist peptide synthesis companies as a lyophilised powder requiring reconstitution
- Capsule form: Some nootropic vendors offer pre-dosed capsules, though the peptide's stability in this format may be questionable
- No pharmaceutical production: Dihexa is not manufactured by any pharmaceutical company and remains exclusively a research compound
- Storage requirements: As a peptide, dihexa should be stored in a cool, dry environment. Reconstituted solutions should be refrigerated and used within a defined timeframe
Frequently asked
A hexapeptide analogue of angiotensin IV developed at Washington State University that is 10 million times more potent than BDNF at promoting synaptogenesis - crossing the blood-brain barrier orally and reversing cognitive deficits in aged animal models through dramatic increases in dendritic spine density.
The main benefits people report from Dihexa are: Cognitive Enhancement, Creativity, Focus, Longevity, Memory.
Animal research doses: In rat studies, effective doses ranged from 0.01 to 2 mg/kg administered orally, intranasally, or intracerebroventricularlyCommunity-reported oral dose: 10-20 mg per day is the most commonly reported oral dose among early adopters in the nootropics community, though this is......
No human safety data: Dihexa has never been tested in human clinical trials. All safety information is extrapolated from animal studies and anecdotal...Theoretical cancer risk: The HGF/c-Met pathway is frequently overactivated in various cancers. Chronic exogenous activation of this growth factor sy...
Dihexa binds to hepatocyte growth factor (HGF) and facilitates its dimerisation, activating the c-Met receptor tyrosine kinase and triggering procognitive...Activates PI3K/Akt and MAPK/ERK pathways downstream of c-Met, stimulating the formation of new synaptic connections between neurons at a potenc...
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