Nootropic profile
Cerebrolysin
A peptide preparation derived from porcine brain tissue containing neurotrophic factors similar to NGF, BDNF, and CNTF - administered by injection and widely used across Eastern Europe, Russia, and China for stroke recovery, traumatic brain injury, Alzheimer's disease, and vascular dementia.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Cerebrolysin?
Cerebrolysin is a unique neuropeptide preparation produced by the standardised enzymatic proteolysis of lipid-free porcine brain tissue.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Cognitive enhancement (off-label): 5 mL by intramuscular injection daily for 10-20 days, repeated in cycles every 3-6 months
- Alzheimer's disease (clinical): 30 mL by intravenous infusion (diluted in saline) daily for 20 consecutive weekdays, with treatment courses repeated every...
- Stroke recovery: 30-50 mL by IV infusion daily, initiated within 72 hours of acute ischaemic stroke and continued for 10-21 days
- Traumatic brain injury: 10-30 mL by IV infusion daily for 10-20 days, depending on injury severity
- Administration: Must be administered by injection only (intramuscular for volumes up to 5 mL, intravenous infusion for larger volumes). Not orally bioavailable
Watch out for
- Injection-only administration: The requirement for IM or IV injection significantly limits accessibility and introduces risks inherent to parenteral drug...
- Common side effects: Dizziness, headache, sweating, and feeling of heat during IV infusion are the most frequently reported adverse effects. These are...
- Allergic reactions: Rare hypersensitivity reactions including skin rash and anaphylaxis have been reported. A test dose may be administered before the first...
- Contraindications: Not recommended in patients with epilepsy (may lower seizure threshold), severe renal impairment, or known allergy to porcine-derived...
- Regulatory status: Approved for clinical use in over 40 countries. Not FDA-approved in the United States. Available by prescription in Russia, China, and...
The science, if you're curious.
- The neuropeptide fraction contains sequences that activate the same receptor systems as endogenous BDNF, NGF, and CNTF, promoting neuronal survival, axonal...
- Reduces glutamate excitotoxicity, inhibits calpain-mediated cell death, and stabilises intracellular calcium levels during ischaemic and traumatic brain...
- Promotes proliferation and differentiation of neural stem cells in the subventricular zone and hippocampal dentate gyrus, supporting the brain's endogenous...
- Enhances synaptophysin expression and increases dendritic branching complexity, restoring synaptic architecture damaged by neurodegeneration, stroke, or...
Where to find it
- EVER Neuro Pharma: The sole manufacturer, producing Cerebrolysin as a sterile aqueous solution in 1 mL, 5 mL, 10 mL, and 30 mL ampoules
- International pharmacies: Available by prescription from pharmacies in Russia, China, and approved countries. Can sometimes be sourced through international pharmacy services
- Medical tourism: Some individuals travel to countries where Cerebrolysin is available to receive treatment cycles under medical supervision
- Cortexin (related product): A similar but distinct peptide preparation from bovine brain cortex, sometimes used as an alternative in countries where it is available
Frequently asked
A peptide preparation derived from porcine brain tissue containing neurotrophic factors similar to NGF, BDNF, and CNTF - administered by injection and widely used across Eastern Europe, Russia, and China for stroke recovery, traumatic brain injury, Alzheimer's disease, and vascular dementia.
The main benefits people report from Cerebrolysin are: Cognitive Enhancement, Creativity, Focus, Longevity, Memory, Mood.
Cognitive enhancement (off-label): 5 mL by intramuscular injection daily for 10-20 days, repeated in cycles every 3-6 monthsAlzheimer's disease (clinical): 30 mL by intravenous infusion (diluted in saline) daily for 20 consecutive weekdays, with treatment courses repeated every...Stroke recover...
Injection-only administration: The requirement for IM or IV injection significantly limits accessibility and introduces risks inherent to parenteral drug...Common side effects: Dizziness, headache, sweating, and feeling of heat during IV infusion are the most frequently reported adverse effects. The...
The neuropeptide fraction contains sequences that activate the same receptor systems as endogenous BDNF, NGF, and CNTF, promoting neuronal survival, axonal...Reduces glutamate excitotoxicity, inhibits calpain-mediated cell death, and stabilises intracellular calcium levels during ischaemic and traum...
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