Nootropic profile
Centrophenoxine
Centrophenoxine (Meclofenoxate) is a synthetic nootropic combining DMAE with an auxin plant hormone. It is a potent cholinergic compound that clears lipofuscin (age pigment) from brain cells, boosts acetylcholine, and supports brain energy - making it one of the best-studied anti-ageing nootropics.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Centrophenoxine?
Centrophenoxine (also known as Meclofenoxate or Lucidril) is a synthetic compound developed in 1959 at the French National Scientific Research Centre. It consists of DMAE (dimethylaminoethanol) bonded to pCPA (para-chlorophenoxyacetic acid, a synthetic auxin).
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Typical dose: 250–750 mg per day, divided into 1–2 doses
- For cognitive support: 250 mg, 1–2 times daily
- For anti-ageing: 500–750 mg daily
- As a choline source: 250 mg can be stacked with racetams to provide choline and prevent headaches
- Best taken: In the morning and early afternoon with food
Watch out for
- Side effects: Generally well-tolerated. Possible headache, nausea, GI discomfort, or insomnia at higher doses.
- Cholinergic excess: At very high doses, may cause symptoms of acetylcholine excess (muscle tension, jaw clenching, irritability). Reduce dose if this occurs.
- Drug interactions: May interact with anticholinergic medications and cholinesterase inhibitors used for Alzheimer's disease.
- Contraindications: Avoid with bipolar disorder, epilepsy, or Parkinson's disease (may worsen symptoms).
- Pregnancy: Not recommended due to insufficient safety data.
The science, if you're curious.
- Uniquely reduces the accumulation of lipofuscin (cellular waste/age pigment) in neurons - one of very few compounds proven to do this in both animal and...
- DMAE moiety is converted to choline and subsequently acetylcholine, supporting memory, learning, and cognitive function.
- Increases phosphatidylcholine and phosphatidylserine in brain cell membranes, improving structural integrity and signal transduction.
- Improves glucose uptake and oxygen utilisation in brain cells, enhancing cellular energy production.
Where to find it
- Synthetic compound: Does not occur in nature - it is a laboratory-synthesised combination of DMAE and pCPA
- Supplements: Available as capsules and powder from nootropic vendors
- Brand name: Lucidril (prescription in parts of Europe)
Frequently asked
Centrophenoxine (Meclofenoxate) is a synthetic nootropic combining DMAE with an auxin plant hormone. It is a potent cholinergic compound that clears lipofuscin (age pigment) from brain cells, boosts acetylcholine, and supports brain energy - making it one of the best-studied anti-ageing nootropics.
The main benefits people report from Centrophenoxine are: Cognitive Enhancement, Energy, Focus, Longevity, Memory, Mood.
Typical dose: 250–750 mg per day, divided into 1–2 dosesFor cognitive support: 250 mg, 1–2 times dailyFor anti-ageing: 500–750 mg dailyAs a choline source: 250 mg can be stacked with racetams to provide choline and prevent headachesBest taken: In the morning and early afternoon with food
Side effects: Generally well-tolerated. Possible headache, nausea, GI discomfort, or insomnia at higher doses.Cholinergic excess: At very high doses, may cause symptoms of acetylcholine excess (muscle tension, jaw clenching, irritability). Reduce dose if this occurs.Drug interactions: May interact w...
Uniquely reduces the accumulation of lipofuscin (cellular waste/age pigment) in neurons - one of very few compounds proven to do this in both animal and...DMAE moiety is converted to choline and subsequently acetylcholine, supporting memory, learning, and cognitive function.Increases phosphatidylcho...
Rate Centrophenoxine
Log in to leave an overall rating.
What people are saying
Log in to leave a comment.
No comments yet. Be the first to share your experience.