Nootropic profile
Bromantane
An atypical psychostimulant with combined anxiolytic and stimulant properties - upregulates tyrosine hydroxylase to boost endogenous dopamine synthesis without the tolerance or withdrawal typical of traditional stimulants.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Bromantane?
Bromantane (Ladasten) is a unique synthetic compound developed by the Russian Academy of Medical Sciences in the 1980s.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Standard dosage: 50-100 mg per day, taken in the morning
- Russian clinical dosage: 50 mg twice daily (100 mg/day) was the approved dosage for asthenia in Russia
- Onset: Acute effects within 1-2 hours. Gene expression changes (TH upregulation) build over days to weeks of consistent use
- Duration: Effects last approximately 8-12 hours
- Cycling: Some users cycle 4 weeks on, 1-2 weeks off, though the lack of reuptake inhibition may make this less necessary than with traditional stimulants
Watch out for
- Russian clinical approval: Approved in Russia as Ladasten since 2002 with a favourable safety profile in clinical use
- WADA banned: Listed as a banned stimulant by the World Anti-Doping Agency. Not suitable for competitive athletes
- Limited Western clinical data: While Russian clinical trials exist, large Western-standard randomised controlled trials are lacking
- Mild side effects: Reported side effects are generally mild - occasional headache, dry mouth, or mild GI discomfort
- Drug interactions: Theoretical interactions with other dopaminergic or GABAergic substances. Avoid combining with MAOIs
The science, if you're curious.
- Increases gene expression of tyrosine hydroxylase, the rate-limiting enzyme in dopamine and norepinephrine synthesis, enhancing endogenous catecholamine...
- Upregulates aromatic L-amino acid decarboxylase, the second enzyme in the dopamine synthesis pathway, further supporting dopamine production
- Enhances GABA-ergic transmission, producing anxiolytic effects without sedation - the source of its calm focus profile
- Influences serotonergic activity in the hippocampus, contributing to its mood-stabilising and memory-supporting effects
Where to find it
- Powder: Available from research chemical suppliers and specialist nootropic vendors
- Capsules: Pre-dosed capsules available from some nootropic retailers
- Sublingual solutions: Some vendors offer liquid preparations for sublingual dosing
Frequently asked
An atypical psychostimulant with combined anxiolytic and stimulant properties - upregulates tyrosine hydroxylase to boost endogenous dopamine synthesis without the tolerance or withdrawal typical of traditional stimulants.
The main benefits people report from Bromantane are: Anxiety & Calm, Energy, Focus, Mood, Motivation, Stress Relief.
Standard dosage: 50-100 mg per day, taken in the morningRussian clinical dosage: 50 mg twice daily (100 mg/day) was the approved dosage for asthenia in RussiaOnset: Acute effects within 1-2 hours. Gene expression changes (TH upregulation) build over days to weeks of consistent useDuration: Effects l...
Russian clinical approval: Approved in Russia as Ladasten since 2002 with a favourable safety profile in clinical useWADA banned: Listed as a banned stimulant by the World Anti-Doping Agency. Not suitable for competitive athletesLimited Western clinical data: While Russian clinical trials exist, lar...
Increases gene expression of tyrosine hydroxylase, the rate-limiting enzyme in dopamine and norepinephrine synthesis, enhancing endogenous catecholamine...Upregulates aromatic L-amino acid decarboxylase, the second enzyme in the dopamine synthesis pathway, further supporting dopamine productionEnhan...
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