Nootropic profile
BPC-157
A synthetic peptide derived from a naturally occurring gastric protein - researched for remarkable tissue repair, neuroprotection, and gut-brain axis modulation, increasingly used in the biohacking community for cognitive recovery.
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide (15 amino acids) derived from a protein naturally found in human gastric juice.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Oral dosage: 250-500 mcg (micrograms) per day, taken on an empty stomach. Oral BPC-157 is increasingly popular as it is stable in gastric acid
- Subcutaneous injection: 250-500 mcg per day, typically near the site of injury or subcutaneously in the abdomen. Injection provides higher systemic...
- Nasal spray: Intranasal administration (250-500 mcg) used for targeted brain effects
- Cycling: Common protocols use 4-8 weeks on, followed by a break of similar duration
- Onset: Tissue healing effects may be noticed within days. Cognitive and mood effects typically develop over 1-4 weeks
Watch out for
- Limited human trial data: While over 100 animal studies exist, published human clinical trials are very limited. Most human evidence is anecdotal
- Animal safety profile: No lethal dose has been established in animal studies, and no significant toxicity has been reported at any dose tested
- Cancer concern: BPC-157 promotes angiogenesis and growth factor signalling. Individuals with active cancer or high cancer risk should exercise extreme...
- Regulatory status: Not approved as a medicine in any jurisdiction. Sold as a "research peptide." Quality and purity vary significantly between suppliers
- Pregnancy and breastfeeding: No safety data exists. Avoid during pregnancy and breastfeeding
The science, if you're curious.
- Interacts with both eNOS (protective) and iNOS (inflammatory) pathways, promoting beneficial vasodilation while reducing neuroinflammatory NO production
- Increases expression of growth hormone receptors, enhancing the trophic and regenerative effects of endogenous growth hormone on neural tissue
- Modulates the dopaminergic system bidirectionally, counteracting both dopamine excess and depletion-related dysfunction
- Enhances serotonin synthesis in specific brain regions, supporting mood and stress resilience
Where to find it
- Oral capsules: BPC-157 in acid-stable capsule form, available from peptide and nootropic retailers
- Lyophilised powder for injection: Reconstituted with bacteriostatic water for subcutaneous injection. Requires sterile technique
- Nasal spray: Pre-made nasal spray formulations available from some vendors
- Quality note: Purchase only from reputable suppliers who provide third-party testing certificates of analysis (COAs) for purity and identity
Frequently asked
A synthetic peptide derived from a naturally occurring gastric protein - researched for remarkable tissue repair, neuroprotection, and gut-brain axis modulation, increasingly used in the biohacking community for cognitive recovery.
The main benefits people report from BPC-157 are: Anxiety & Calm, Cognitive Enhancement, Energy, Longevity, Mood, Stress Relief.
Oral dosage: 250-500 mcg (micrograms) per day, taken on an empty stomach. Oral BPC-157 is increasingly popular as it is stable in gastric acidSubcutaneous injection: 250-500 mcg per day, typically near the site of injury or subcutaneously in the abdomen. Injection provides higher systemic...Nasal sp...
Limited human trial data: While over 100 animal studies exist, published human clinical trials are very limited. Most human evidence is anecdotalAnimal safety profile: No lethal dose has been established in animal studies, and no significant toxicity has been reported at any dose testedCancer concer...
Interacts with both eNOS (protective) and iNOS (inflammatory) pathways, promoting beneficial vasodilation while reducing neuroinflammatory NO productionIncreases expression of growth hormone receptors, enhancing the trophic and regenerative effects of endogenous growth hormone on neural tissueModula...
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