Nootropic profile
Aniracetam
Aniracetam is a fat-soluble racetam nootropic known for its combined cognitive-enhancing and anxiolytic effects. It modulates AMPA receptors, enhances creativity and verbal fluency, and reduces anxiety - making it popular for both focus and social situations.
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Aniracetam?
Aniracetam (1-p-anisoyl-2-pyrrolidinone) is a fat-soluble racetam compound developed by Hoffmann-La Roche in the 1970s.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Typical dose: 750–1,500 mg per day, divided into 2–3 doses
- Common protocol: 750 mg twice daily
- Half-life: Short (1–2.5 hours) - multiple daily doses are necessary for sustained effects
- Must take with fat: Aniracetam is fat-soluble and must be taken with a meal or fat source (e.g. fish oil, MCT oil) for proper absorption
- With choline: Often stacked with Alpha-GPC or citicoline to prevent headaches and enhance cholinergic effects
Watch out for
- Side effects: Generally well-tolerated. Possible headache (mitigated by choline supplementation), mild GI discomfort, or insomnia if taken late.
- Toxicity: Very low. Animal studies show extremely high LD50 values. No deaths attributed to aniracetam in humans.
- Drug interactions: Limited data. Use caution with other cholinergic or glutamatergic compounds.
- Pregnancy: Not recommended due to insufficient safety data.
- Legal status: Prescription medication in Europe and Japan (Ampamet, Draganon). Sold as a dietary supplement or research chemical in the US and UK.
The science, if you're curious.
- Aniracetam is one of the first identified AMPAkines - it positively modulates AMPA glutamate receptors, enhancing synaptic transmission, long-term...
- Increases acetylcholine release in the prefrontal cortex and hippocampus, supporting memory, attention, and learning.
- Increases dopamine and serotonin release in the prefrontal cortex, contributing to its anxiolytic and mood-enhancing properties.
- Reduces desensitisation of mGluR receptors, further supporting glutamatergic signalling for learning and memory.
Where to find it
- Synthetic compound: Does not occur in nature - must be synthesised
- Supplements: Available as capsules and powder from nootropic vendors
- Brand names: Ampamet (Italy), Draganon (Japan), Referan (various)
Frequently asked
Aniracetam is a fat-soluble racetam nootropic known for its combined cognitive-enhancing and anxiolytic effects. It modulates AMPA receptors, enhances creativity and verbal fluency, and reduces anxiety - making it popular for both focus and social situations.
The main benefits people report from Aniracetam are: Anxiety & Calm, Cognitive Enhancement, Creativity, Focus, Memory, Mood.
Typical dose: 750–1,500 mg per day, divided into 2–3 dosesCommon protocol: 750 mg twice dailyHalf-life: Short (1–2.5 hours) - multiple daily doses are necessary for sustained effectsMust take with fat: Aniracetam is fat-soluble and must be taken with a meal or fat source (e.g. fish oil, MCT oil) for...
Side effects: Generally well-tolerated. Possible headache (mitigated by choline supplementation), mild GI discomfort, or insomnia if taken late.Toxicity: Very low. Animal studies show extremely high LD50 values. No deaths attributed to aniracetam in humans.Drug interactions: Limited data. Use cautio...
Aniracetam is one of the first identified AMPAkines - it positively modulates AMPA glutamate receptors, enhancing synaptic transmission, long-term...Increases acetylcholine release in the prefrontal cortex and hippocampus, supporting memory, attention, and learning.Increases dopamine and serotonin r...
Rate Aniracetam
Log in to leave an overall rating.
What people are saying
Log in to leave a comment.
No comments yet. Be the first to share your experience.