Nootropic profile
Agmatine Sulfate
A naturally occurring neuromodulator derived from the amino acid arginine that modulates NMDA receptors, nitric oxide, and multiple neurotransmitter systems for mood enhancement, pain relief, and neuroprotection.
Best for
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Agmatine Sulfate?
Agmatine is a biogenic amine produced by the decarboxylation of L-arginine. It was discovered in 1910 but its role as a neurotransmitter and neuromodulator was not recognised until the 1990s, when it was found to be synthesised, stored, and released by neurons in the brain.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Standard dosage: 500-1,000 mg of agmatine sulfate, one to three times daily
- Mood support: 1,000-2,000 mg per day, divided into two doses
- Pain management: Up to 2,670 mg per day was used safely in clinical trials for neuropathic pain
- Timing: Can be taken with or without food. Some users report better absorption on an empty stomach
- Onset: Effects on mood may be noticed within days to weeks. Pain relief effects may take 2-4 weeks of consistent use
Watch out for
- Generally well tolerated: Mild gastrointestinal discomfort is the most common side effect at higher doses
- Avoid with protein supplements: Arginine and citrulline may compete with agmatine for absorption and metabolism
- Blood pressure: May lower blood pressure - use caution if already taking antihypertensive medications
- Limited long-term human data: While animal safety data is reassuring, long-term human trials are limited
- Pregnancy and breastfeeding: Insufficient safety data - avoid during pregnancy and breastfeeding
The science, if you're curious.
- Blocks NMDA receptors at the polyamine binding site, reducing glutamate excitotoxicity and contributing to antidepressant and neuroprotective effects
- Selectively inhibits neuronal NOS (nNOS) and inducible NOS (iNOS), reducing nitric oxide-mediated oxidative stress
- Activates I1 and I2 imidazoline receptors, which regulate blood pressure, insulin release, and neurotransmitter function
- Modulates norepinephrine release, contributing to anxiolytic and analgesic effects
Where to find it
- Agmatine sulfate powder: Available from nootropic suppliers (Nootropics Depot, Bulk Supplements) in powder or capsule form
- Capsules: Typically 500-1,000 mg per capsule
- Food sources: Small amounts found in fermented foods, wine, beer, and certain fish, but far below supplemental doses
Frequently asked
A naturally occurring neuromodulator derived from the amino acid arginine that modulates NMDA receptors, nitric oxide, and multiple neurotransmitter systems for mood enhancement, pain relief, and neuroprotection.
The main benefits people report from Agmatine Sulfate are: Anxiety & Calm, Cognitive Enhancement, Energy, Focus, Mood, Stress Relief.
Standard dosage: 500-1,000 mg of agmatine sulfate, one to three times dailyMood support: 1,000-2,000 mg per day, divided into two dosesPain management: Up to 2,670 mg per day was used safely in clinical trials for neuropathic painTiming: Can be taken with or without food. Some users report better ab...
Generally well tolerated: Mild gastrointestinal discomfort is the most common side effect at higher dosesAvoid with protein supplements: Arginine and citrulline may compete with agmatine for absorption and metabolismBlood pressure: May lower blood pressure - use caution if already taking antihyperte...
Blocks NMDA receptors at the polyamine binding site, reducing glutamate excitotoxicity and contributing to antidepressant and neuroprotective effectsSelectively inhibits neuronal NOS (nNOS) and inducible NOS (iNOS), reducing nitric oxide-mediated oxidative stressActivates I1 and I2 imidazoline recep...
Rate Agmatine Sulfate
Log in to leave an overall rating.
What people are saying
Log in to leave a comment.
No comments yet. Be the first to share your experience.