Nootropic profile
Aceglutamide
An acetylated form of L-glutamine (N-acetyl-L-glutamine) with enhanced blood-brain barrier penetration, used in Asia as a nootropic and neuroprotectant for cerebrovascular disorders.
Educational only: this is not medical advice. Always check with a qualified healthcare professional before starting any supplement.
What is Aceglutamide?
Aceglutamide (N-acetyl-L-glutamine) is an acetylated derivative of the amino acid L-glutamine that was developed to improve the delivery of glutamine to the central nervous system.
What it does for you
Community and editorial ratings, out of 5:
How to take it
- Oral dosage: 100-300 mg taken two to three times daily (total daily dose of 200-900 mg) in clinical settings in Japan and China
- Injectable form: Aceglutamide Aluminum injection is administered at 100-200 mg via intramuscular or slow intravenous injection in hospital settings for...
- Duration of treatment: Oral treatment courses typically last 4-12 weeks, with some protocols extending to several months for chronic cerebrovascular conditions
- Administration: Oral tablets or capsules taken with meals; the injectable form is reserved for clinical settings under medical supervision
- Availability: Primarily available in Japan, China, and some other Asian countries; not approved by the FDA or EMA, though the compound can be sourced from...
Watch out for
- Generally well-tolerated: Clinical experience in Asian markets has shown a favourable safety profile, with most adverse effects being mild gastrointestinal...
- Aluminum concerns (injectable form): The Aceglutamide Aluminum formulation carries theoretical concerns about aluminum accumulation, particularly with...
- Glutamate sensitivity: As a glutamate precursor, caution is warranted in individuals sensitive to glutamate or those with conditions exacerbated by...
- Renal impairment: Dose adjustment may be necessary in patients with significant renal dysfunction, particularly for the aluminum-containing formulation
- Limited Western safety data: Most safety information comes from Japanese and Chinese post-marketing surveillance, which may not meet Western regulatory...
The science, if you're curious.
- The N-acetyl modification significantly improves blood-brain barrier permeability compared to unmodified L-glutamine, allowing higher CNS bioavailability at...
- Deacetylated in the brain to L-glutamine, which is subsequently converted to glutamate by glutaminase, supporting excitatory neurotransmission essential for...
- Through the glutamate-GABA metabolic pathway (via glutamic acid decarboxylase), serves as an indirect precursor to GABA, supporting inhibitory...
- L-glutamine participates in the glutamate-glutamine cycle between neurons and astrocytes, supporting cerebral energy metabolism and ammonia detoxification...
Where to find it
- Ogawa (1976): Clinical study on Aceglutamide's effects on cognitive function in patients with cerebral arteriosclerosis, published in Japanese Journal of Pharmacology
- Japanese pharmaceutical registry: Product monograph and prescribing information for Aceglutamide tablets and Aceglutamide Aluminum injection as approved in Japan
- Chinese pharmacopoeia: Monograph on Aceglutamide Aluminum injection including quality standards, clinical indications, and dosing guidelines
- Glutamine metabolism review: Albrecht et al. (2010) - "Glutamine in the central nervous system" reviewing the role of glutamine and its derivatives in brain function and pathology
- Blood-brain barrier transport: Gynther et al. (2008) - review of amino acid prodrug strategies for CNS delivery, including N-acetylation approaches exemplified by Aceglutamide
Frequently asked
An acetylated form of L-glutamine (N-acetyl-L-glutamine) with enhanced blood-brain barrier penetration, used in Asia as a nootropic and neuroprotectant for cerebrovascular disorders.
The main benefits people report from Aceglutamide are: Anxiety & Calm, Cognitive Enhancement, Focus, Longevity, Memory, Mood.
Oral dosage: 100-300 mg taken two to three times daily (total daily dose of 200-900 mg) in clinical settings in Japan and ChinaInjectable form: Aceglutamide Aluminum injection is administered at 100-200 mg via intramuscular or slow intravenous injection in hospital settings for...Duration of treatme...
Generally well-tolerated: Clinical experience in Asian markets has shown a favourable safety profile, with most adverse effects being mild gastrointestinal...Aluminum concerns (injectable form): The Aceglutamide Aluminum formulation carries theoretical concerns about aluminum accumulation, particula...
The N-acetyl modification significantly improves blood-brain barrier permeability compared to unmodified L-glutamine, allowing higher CNS bioavailability at...Deacetylated in the brain to L-glutamine, which is subsequently converted to glutamate by glutaminase, supporting excitatory neurotransmissio...
Rate Aceglutamide
Log in to leave an overall rating.
What people are saying
Log in to leave a comment.
No comments yet. Be the first to share your experience.